Overview

We are developing human striatal medium spiny neurons (MSNs) for a cell transplantation therapy targeting Huntington’s Disease.


Huntington’s Disease is an autosomal dominant neurodegenerative disorder caused by an expanded polyglutamine repeat in the huntingtin gene. The neuropathology of HD is characterized by the decline of a specific neuronal population within the brain - the human striatal medium spiny neurons (MSNs).

We are developing these specialized human striatal medium spiny neuronal cells (MSNs) from induced pluripotent stem cells (iPSCs) as the basis for a cell transplantation-based therapy for Huntington’s Disease.

Current Developments

We are developing human striatal medium spiny neurons (MSNs) for a cell transplantation therapy targeting Huntington’s Disease.

We are developing cell culture media for developing MSNs that can be transplanted into the brains of Huntington’s Disease patients.

Our MSN-based cell therapy program is based on promising research into the viability of a cell transplantation therapy for Huntington’s Disease.

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