Forebrain Oligodendrocytes

We have developed a novel three-stage protocol that uses only small molecules to make human oligodendrocyte progenitor cells (OPCs) of the forebrain from human (non-embryo) induced pluripotent stem cells (iPSCs).

Published protocols in the scientific literature use proteins and require 50-90 days while we attain OPC commitment in less than ten days.

Oligodendrocytes can be used to accelerate the drug discovery process for treatments of multiple sclerosis (MS), leukodystrophies, cerebral palsy, and Pelizaeus-Merzbacher Disease.

Forebrain Cortical Interneurons

We are currently developing a novel protocol that will use only small molecules to make human cortical interneurons of the forebrain from human (non-embryo) induced pluripotent stem cells (iPSCs).

Our dopaminergic neurons can be used to accelerate the drug discovery process for treatments of neuropsychiatric disorders, schizophrenia, autism, and intellectual disabilities.

Midbrain Dopaminergic Neurons

We have developed a novel three-stage protocol that uses only small molecules to make human dopaminergic neurons of the midbrain from human (non-embryo) induced pluripotent stem cells (iPSCs).

Our protocol achieves full cell differentiation in only 9 days.

By comparison, published protocols in the scientific literature use proteins and require 50-90 days for full differentiation.

Our dopaminergic neurons can be used to accelerate the drug discovery process for treatments of Parkinson’s Disease.

Medium Spiny Neurons

We are currently developing a novel protocol that will use only small molecules to make human medium spiny neurons from human (non-embryo) induced pluripotent stem cells (iPSCs).

We will use our medium spiny neurons as the foundation for a cell transplantation therapy for treating Huntington’s Disease, which we are developing.

NPY-Expressing Neurons of the Hypothalamus

We are developing these specialized human cells from human (non-embryo) induced pluripotent stem cells (iPSCs) using our proprietary HD-DOE™ research and development platform.

We already have a nascent protocol for the generation of hypothalamic NPY-expressing cells.

We believe that the delivery of specific subsets of hypothalamic cells from iPSC would be a gate-opener for the drug discovery industry.

GLP1-Expressing Neurons of the Hindbrain

We are developing these specialized human cells from human (non-embryo) induced pluripotent stem cells (iPSCs) using our proprietary HD-DOE research and development platform™.

We believe that the delivery of these specific cells from iPSC would be a gate-opener for the drug discovery industry.

Endothelial Cells

We are developing human endothelial cells from human (non-embryo) induced pluripotent stem cells (iPSCs).

Our novel protocol will allow us to make endothelial cells at scale.

We will make our endothelial cells available for drug discovery, organ or tissue printing, high throughput or high content screening, toxicity and efficacy testing, and human disease modeling.

Red Blood Cells (Erythrocytes)

We are developing human red blood cells (Erythrocytes) from human (non-embryo) induced pluripotent stem cells (iPSCs) in a two-step process (iPSCs to HSCs and HSCs to Erythrocytes).

Our novel protocols will use small molecules to make red blood cells, which will allow the production of red blood cells at scale.

We will use our red blood cells as the foundation for a cell therapy for the treatment of blood loss and various blood diseases and disorders, which we are developing.

LT-Hematopoietic Stem Cells

We are developing human long-term hematopoietic stem cells (LT-HSCs) from human (non-embryo) induced pluripotent stem cells (iPSCs).

HSCs are rare subsets of hematopoietic cells that are responsible for the life-long production of all blood cell lineages, and for the reconstitution of bone marrow (BM) after transplantation into myeloablative recipients.

We will use our LT-HSCs cells as the foundation for cell therapy for bone marrow failure, which we are developing, in particular, as a cell replacement therapy — in lieu of a bone marrow transplant — for patients whose bone marrow stems cells have been permanently damaged or destroyed.

T-Cell Subtypes from Naive T-Cells

We are developing cell culture media for T-cell subtype control to improve clinical potency in the individual patient and reduction of variability in outcomes between patients.

CAR T-cell therapy involves the treatment of cancer by modifying a patient’s T-cells in the lab so they will attack cancer cells. If clinical development of the CART T-cell produces the wrong T-cell subtype, patient outcome will suffer.

Our T-Cell Subtype cell therapy program aims to improve the efficacy of CAR T-cell therapies.

Platelets (Megakaryocytes)

We are developing human platelets (Megakaryocytes) from human (non-embryo) induced pluripotent stem cells (iPSCs) in a two-step process (iPSCs to HSCs and HSCs to Megakaryocytes).

Our novel protocols will use small molecules to make platelets, which will allow production of platelets at scale.

We will use our platelets as the foundation for a cell therapy for the treatment of blood loss and various blood diseases and disorders, which we are developing.

Pancreatic Insulin Producing Cells (Beta Cells)

We have developed a novel protocol that uses only small molecules to make dorsal pancreatic insulin-producing cells (beta cells) from human (non-embryo) induced pluripotent stem cells (iPSCs).

By comparison, published protocols in the scientific literature are more complex and use proteins, which results in significantly greater costs.

We will make our pancreatic insulin-producing cells available for drug discovery, organ or tissue printing, high throughput screening, high content screening, toxicity testing, efficacy testing, and human disease modeling

We will use our pancreatic insulin-producing cells as the foundation for a cell therapy for treating Type I Diabetes, which we are developing.